High and escalating levels of cocaine intake are dissociable from subsequent incentive motivation for the drug in rats.
Identifieur interne : 000919 ( Main/Exploration ); précédent : 000918; suivant : 000920High and escalating levels of cocaine intake are dissociable from subsequent incentive motivation for the drug in rats.
Auteurs : Florence Allain [Canada] ; Karim Bouayad-Gervais [Canada] ; Anne-Noël Samaha [Canada]Source :
- Psychopharmacology [ 1432-2072 ] ; 2018.
Descripteurs français
- KwdFr :
- Animaux (MeSH), Autoadministration (MeSH), Cocaïne (administration et posologie), Cocaïne (pharmacologie), Comportement de recherche de substances (effets des médicaments et des substances chimiques), Comportement toxicomaniaque (MeSH), Encéphale (effets des médicaments et des substances chimiques), Modèles animaux de maladie humaine (MeSH), Motivation (effets des médicaments et des substances chimiques), Mâle (MeSH), Rats (MeSH), Relation dose-effet des médicaments (MeSH), Troubles liés à la cocaïne (MeSH).
- MESH :
- administration et posologie : Cocaïne.
- effets des médicaments et des substances chimiques : Comportement de recherche de substances, Encéphale, Motivation.
- pharmacologie : Cocaïne.
- Animaux, Autoadministration, Comportement toxicomaniaque, Modèles animaux de maladie humaine, Mâle, Rats, Relation dose-effet des médicaments, Troubles liés à la cocaïne.
English descriptors
- KwdEn :
- Animals (MeSH), Behavior, Addictive (MeSH), Brain (drug effects), Cocaine (administration & dosage), Cocaine (pharmacology), Cocaine-Related Disorders (MeSH), Disease Models, Animal (MeSH), Dose-Response Relationship, Drug (MeSH), Drug-Seeking Behavior (drug effects), Male (MeSH), Motivation (drug effects), Rats (MeSH), Reinforcement, Psychology (MeSH), Self Administration (MeSH).
- MESH :
- chemical , administration & dosage : Cocaine.
- drug effects : Brain, Drug-Seeking Behavior, Motivation.
- chemical , pharmacology : Cocaine.
- Animals, Behavior, Addictive, Cocaine-Related Disorders, Disease Models, Animal, Dose-Response Relationship, Drug, Male, Rats, Reinforcement, Psychology, Self Administration.
Abstract
RATIONALE
Taking high and increasing amounts of cocaine is thought to be necessary for the development of addiction. Consequently, a widely used animal model of drug self-administration involves giving animals continuous drug access during long sessions (LgA), as this produces high and escalating levels of intake. However, human cocaine addicts likely use the drug with an intermittent rather than continuous pattern, producing spiking brain cocaine levels.
OBJECTIVES
Using an intermittent-access (IntA) cocaine self-administration procedure in rats, we studied the relationship between escalation of cocaine intake and later incentive motivation for the drug, as measured by responding under a progressive ratio schedule of cocaine reinforcement.
RESULTS
First, under IntA, rats escalated their cocaine use both within and between sessions. However, escalation did not predict later incentive motivation for the drug. Second, incentive motivation for cocaine was similar in IntA-rats limited to low- and non-escalating levels of drug intake (IntA-Lim) and in IntA-rats that took high and escalating levels of drug. Finally, IntA-Lim rats took much less cocaine than rats given continuous drug access during each self-administration session (LgA-rats). However, IntA-Lim rats later responded more for cocaine under a progressive ratio schedule of reinforcement.
CONCLUSIONS
Taking large and escalating quantities of cocaine does not appear necessary to increase incentive motivation for the drug. Taking cocaine in an intermittent pattern-even in small amounts-is more effective in producing this addiction-relevant change. Thus, beyond the amount of drug taken, the temporal kinetics of drug use predict change in drug use over time.
DOI: 10.1007/s00213-017-4773-8
PubMed: 29085961
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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Anna.samaha@umontreal.ca.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>CNS Research Group, Faculty of Medicine, Université de Montréal, Montreal, QC, H3C 3J7</wicri:regionArea><wicri:noRegion>H3C 3J7</wicri:noRegion></affiliation></author></analytic><series><title level="j">Psychopharmacology</title><idno type="eISSN">1432-2072</idno><imprint><date when="2018" type="published">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term><term>Behavior, Addictive (MeSH)</term><term>Brain (drug effects)</term><term>Cocaine (administration & dosage)</term><term>Cocaine (pharmacology)</term><term>Cocaine-Related Disorders (MeSH)</term><term>Disease Models, Animal (MeSH)</term><term>Dose-Response Relationship, Drug (MeSH)</term><term>Drug-Seeking Behavior (drug effects)</term><term>Male (MeSH)</term><term>Motivation (drug effects)</term><term>Rats (MeSH)</term><term>Reinforcement, Psychology (MeSH)</term><term>Self Administration (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux (MeSH)</term><term>Autoadministration (MeSH)</term><term>Cocaïne (administration et posologie)</term><term>Cocaïne (pharmacologie)</term><term>Comportement de recherche de substances (effets des médicaments et des substances chimiques)</term><term>Comportement toxicomaniaque (MeSH)</term><term>Encéphale (effets des médicaments et des substances chimiques)</term><term>Modèles animaux de maladie humaine (MeSH)</term><term>Motivation (effets des médicaments et des substances chimiques)</term><term>Mâle (MeSH)</term><term>Rats (MeSH)</term><term>Relation dose-effet des médicaments (MeSH)</term><term>Troubles liés à la cocaïne (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Cocaine</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Cocaïne</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Brain</term><term>Drug-Seeking Behavior</term><term>Motivation</term></keywords><keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Comportement de recherche de substances</term><term>Encéphale</term><term>Motivation</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Cocaïne</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Cocaine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Behavior, Addictive</term><term>Cocaine-Related Disorders</term><term>Disease Models, Animal</term><term>Dose-Response Relationship, Drug</term><term>Male</term><term>Rats</term><term>Reinforcement, Psychology</term><term>Self Administration</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Autoadministration</term><term>Comportement toxicomaniaque</term><term>Modèles animaux de maladie humaine</term><term>Mâle</term><term>Rats</term><term>Relation dose-effet des médicaments</term><term>Troubles liés à la cocaïne</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>RATIONALE</b></p><p>Taking high and increasing amounts of cocaine is thought to be necessary for the development of addiction. Consequently, a widely used animal model of drug self-administration involves giving animals continuous drug access during long sessions (LgA), as this produces high and escalating levels of intake. However, human cocaine addicts likely use the drug with an intermittent rather than continuous pattern, producing spiking brain cocaine levels.</p></div><div type="abstract" xml:lang="en"><p><b>OBJECTIVES</b></p><p>Using an intermittent-access (IntA) cocaine self-administration procedure in rats, we studied the relationship between escalation of cocaine intake and later incentive motivation for the drug, as measured by responding under a progressive ratio schedule of cocaine reinforcement.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>First, under IntA, rats escalated their cocaine use both within and between sessions. However, escalation did not predict later incentive motivation for the drug. Second, incentive motivation for cocaine was similar in IntA-rats limited to low- and non-escalating levels of drug intake (IntA-Lim) and in IntA-rats that took high and escalating levels of drug. Finally, IntA-Lim rats took much less cocaine than rats given continuous drug access during each self-administration session (LgA-rats). However, IntA-Lim rats later responded more for cocaine under a progressive ratio schedule of reinforcement.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>Taking large and escalating quantities of cocaine does not appear necessary to increase incentive motivation for the drug. Taking cocaine in an intermittent pattern-even in small amounts-is more effective in producing this addiction-relevant change. Thus, beyond the amount of drug taken, the temporal kinetics of drug use predict change in drug use over time.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" IndexingMethod="Curated" Owner="NLM"><PMID Version="1">29085961</PMID><DateCompleted><Year>2018</Year><Month>12</Month><Day>19</Day></DateCompleted><DateRevised><Year>2019</Year><Month>12</Month><Day>10</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1432-2072</ISSN><JournalIssue CitedMedium="Internet"><Volume>235</Volume><Issue>1</Issue><PubDate><Year>2018</Year><Month>01</Month></PubDate></JournalIssue><Title>Psychopharmacology</Title><ISOAbbreviation>Psychopharmacology (Berl)</ISOAbbreviation></Journal><ArticleTitle>High and escalating levels of cocaine intake are dissociable from subsequent incentive motivation for the drug in rats.</ArticleTitle><Pagination><MedlinePgn>317-328</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1007/s00213-017-4773-8</ELocationID><Abstract><AbstractText Label="RATIONALE">Taking high and increasing amounts of cocaine is thought to be necessary for the development of addiction. Consequently, a widely used animal model of drug self-administration involves giving animals continuous drug access during long sessions (LgA), as this produces high and escalating levels of intake. However, human cocaine addicts likely use the drug with an intermittent rather than continuous pattern, producing spiking brain cocaine levels.</AbstractText><AbstractText Label="OBJECTIVES">Using an intermittent-access (IntA) cocaine self-administration procedure in rats, we studied the relationship between escalation of cocaine intake and later incentive motivation for the drug, as measured by responding under a progressive ratio schedule of cocaine reinforcement.</AbstractText><AbstractText Label="RESULTS">First, under IntA, rats escalated their cocaine use both within and between sessions. However, escalation did not predict later incentive motivation for the drug. Second, incentive motivation for cocaine was similar in IntA-rats limited to low- and non-escalating levels of drug intake (IntA-Lim) and in IntA-rats that took high and escalating levels of drug. Finally, IntA-Lim rats took much less cocaine than rats given continuous drug access during each self-administration session (LgA-rats). However, IntA-Lim rats later responded more for cocaine under a progressive ratio schedule of reinforcement.</AbstractText><AbstractText Label="CONCLUSIONS">Taking large and escalating quantities of cocaine does not appear necessary to increase incentive motivation for the drug. Taking cocaine in an intermittent pattern-even in small amounts-is more effective in producing this addiction-relevant change. Thus, beyond the amount of drug taken, the temporal kinetics of drug use predict change in drug use over time.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Allain</LastName><ForeName>Florence</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Department of Pharmacology and Physiology, Faculty of Medicine, Université de Montréal, C.P. 6128, Succursale Centre-ville, Montreal, QC, H3C 3J7, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bouayad-Gervais</LastName><ForeName>Karim</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Pharmacology and Physiology, Faculty of Medicine, Université de Montréal, C.P. 6128, Succursale Centre-ville, Montreal, QC, H3C 3J7, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Samaha</LastName><ForeName>Anne-Noël</ForeName><Initials>AN</Initials><AffiliationInfo><Affiliation>Department of Pharmacology and Physiology, Faculty of Medicine, Université de Montréal, C.P. 6128, Succursale Centre-ville, Montreal, QC, H3C 3J7, Canada. Anna.samaha@umontreal.ca.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>CNS Research Group, Faculty of Medicine, Université de Montréal, Montreal, QC, H3C 3J7, Canada. Anna.samaha@umontreal.ca.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>157572</GrantID><Agency>CIHR</Agency><Country>Canada</Country></Grant><Grant><GrantID>24326</GrantID><Agency>Canada Foundation for Innovation</Agency><Country>International</Country></Grant><Grant><GrantID>28988</GrantID><Agency>Fonds de Recherche du Québec - Santé</Agency><Country>International</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>10</Month><Day>31</Day></ArticleDate></Article><MedlineJournalInfo><Country>Germany</Country><MedlineTA>Psychopharmacology (Berl)</MedlineTA><NlmUniqueID>7608025</NlmUniqueID><ISSNLinking>0033-3158</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>I5Y540LHVR</RegistryNumber><NameOfSubstance UI="D003042">Cocaine</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016739" MajorTopicYN="N">Behavior, Addictive</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001921" MajorTopicYN="N">Brain</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003042" MajorTopicYN="Y">Cocaine</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019970" MajorTopicYN="Y">Cocaine-Related Disorders</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004195" MajorTopicYN="N">Disease Models, Animal</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004305" MajorTopicYN="N">Dose-Response Relationship, Drug</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D058999" MajorTopicYN="N">Drug-Seeking Behavior</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009042" MajorTopicYN="N">Motivation</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051381" MajorTopicYN="N">Rats</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012054" MajorTopicYN="N">Reinforcement, Psychology</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012646" MajorTopicYN="N">Self Administration</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Addiction</Keyword><Keyword MajorTopicYN="Y">Binge-like cocaine intake</Keyword><Keyword MajorTopicYN="Y">Escalation of cocaine intake</Keyword><Keyword MajorTopicYN="Y">Intermittent access</Keyword><Keyword MajorTopicYN="Y">Intravenous drug self-administration</Keyword><Keyword MajorTopicYN="Y">Long access</Keyword><Keyword MajorTopicYN="Y">Progressive ratio</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2017</Year><Month>08</Month><Day>11</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2017</Year><Month>10</Month><Day>20</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>11</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate 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